|This character is essential. Essential characters cannot be killed.|
|This character is a temporary companion.|
|This character is a permanent companion. They grant the - perk.|
|This character is a doctor.|
|This character is a merchant.||Caps: -|
|This character can repair items.||Repair cap: -|
|This character can modify weapons.||
|This character rents beds.||Cost: - caps.|
|This character starts quests.||
|This character is involved in quests.|
Even though Nick Valentine claims that all synths who escape the Institute lose their memories of it, surmising that this is due to a manufacturing failsafe, H2-22 can recall many details of his life there. It is later revealed by DiMA that Nick had a new brain uploaded to him just before the two of them escaped, coupled with the early synth's limited memory capacity caused Nick to not remember the Institute.
H2-22 appears only in Fallout 4.