To read a holodisk in Fallout, left-click the disk in your inventory and hold the mouse-button, then select the open hand-icon (use). Enter the Pipboy, click the status button and hunt down the file from the list on the right.
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For locations and transcripts please refer to the individual articles.
Cutscenes ·Holodisks and notes ·Terminal entries ·Vault Dweller's Survival Guide: Pocket Reference Edition ·Dialogue files ·Fallout 3 manual ·Fallout 3 Official Game Guide (Faction profiles ·Wasteland Census · Location profiles: (Tour of The Capital Wasteland ·Tour of Operation: Anchorage ·Tour of The Pitt ·Tour of Broken Steel ·Tour of Point Lookout ·Tour of Mothership Zeta) ·Afterward)