Jacobstown sits at the same general location as the pre-war settlement of Mount Charleston, a small alpine community high in the mountains west of the Las Vegas Valley. Post-war, the area was of little interest to travelers and scavengers due to its remote location and lack of salvageable material. It was not until the past twenty years that it became a permanent settlement for any group. 雅各布斯鎮的名字來源於雅各布：一名鋼鐵兄弟會的聖騎士，和馬庫斯結伴一同發現了破碎嶺。馬庫斯為紀念這位老朋友，用他的名字命名了此地。後來成為當地警長的馬庫斯 took it upon himself to find a refuge for the 「broken-minded」 of his kind— low-intelligence super mutants and schizophrenic nightkin. It proved to be more difficult than holding on to Broken Hills, but he eventually discovered Mount Charleston and decided it was a good spot to set up a community.
Unfortunately for Marcus, not all of the nightkin were content to live under his rules. Davison (who currently talks to a brahmin Skull named Antler in the bowels of the REPCONN test site) and Tabitha (who broadcasts her particular brand of insanity from Black Mountain) broke off on their own, eventually winding up with their own dysfunctional super mutant communities. Though Marcus is disappointed at how things turned out, he does the best he can to take care of Lily and the other super mutants and nightkin at Jacobstown.
- 在一排民房後有一間房子，裡面一張散亂著撲克牌的桌子上有 枚「夕陽沙士星星瓶蓋」
Narrated by Marcus.
|#||Slide||Voice-over narration||In-game condition|
|1||With Jacobstown's leadership destroyed, the remaining super mutants and nightkin of the west scattered across the wasteland. Jacobstown withered away, its death going unnoticed by the rest of the Mojave.||Marcus dies.|
|2||Thanks to the Courier and Lily, a cure for the nightkin's schizophrenia was found shortly after Doctor Henry's experiment concluded. Nightkin and other super mutants in the wasteland flocked to Jacobstown, and the town became known as a haven where a mutant could find peace.||Complete Guess Who I Saw Today, pass the Speech check with Keene and Science check with Doctor Henry, or encourage Doctor Henry to continue his tests on Lily.|
|3||Though a cure for the nightkin's schizophrenia was eventually found, it became a case of too little, too late for Jacobstown. Disgruntled by the death of their leader, Keene, most of the nightkin scattered into the wasteland, their insanity worsening with each day. Jacobstown, constantly on guard for anti-mutant reprisals, never truly prospered.||Complete Guess Who I Saw Today, Keene dies during the quest.|
|4||Though a cure for the nightkin's schizophrenia was eventually found, it became a case of too little, too late for Jacobstown. Most nightkin at Jacobstown followed their leader Keene out into the wasteland, terrorizing the Mojave for years to come. Jacobstown, constantly on guard for anti-mutant reprisals, never truly prospered.||Complete Guess Who I Saw Today, failing the Speech check with Keene (but allowing him to leave) and passing the Science check with Doctor Henry.|
|5||It took more time than anticipated for a cure for the nightkin's schizophrenia to be found, but in the end it was beneficial to Jacobstown. The presence of the nightkin leader, Keene, persuaded nightkin from across the wasteland to make the journey to the town. Jacobstown prospered, becoming known as a fair - if somewhat intimidating - place for a trader to do business.||Complete Guess Who I Saw Today, passing the Speech check with Keene and failing (or ignoring) the Science check with Doctor Henry.|
|6||With no cure for the nightkin's schizophrenia in sight, the disgruntled nightkin left Jacobstown. Without a treatment, their insanity grew. The crazed nightkin terrorized the wasteland, and Jacobstown suffered repeated reprisals from mutant-hating humans. In the end, the surviving mutants abandoned Jacobstown entirely, its existence quickly forgotten by the rest of the wasteland.||Complete Guess Who I Saw Today, failing (or ignoring) both the Speech check with Keene and the Science check with Doctor Henry, or do not complete the quest.|
- Other than the super mutants and nightkin, Jacobstown is also home to an unnamed super mutant master. He has a "normal," cultured voice (similar to Neil's), instead of the more gravelly voice used by the other super mutants, but says the same generic dialogue phrases.
- Although the Nightkin will warn you not to stare at them, doing this will not turn them hostile.
- In an upstairs room of the lodge, there is the one and only pinball machine in the game.
- The mutants appear to still have an interest in heavy weaponry and destruction; when spoken to, the normal mutants will comment about wanting miniguns or missile launchers from Marcus.
- At higher levels, cazadores will often spawn near the front gate to Jacobstown, and may attack the super mutants.
- 雅各布斯鎮坐落於戰前同時也是現實的小鎮查爾斯頓山, 位於拉斯維加斯谷西邊的山上。在雅各布斯鎮指標上， 可以隱約查爾斯頓山字樣。