货运机器人完全没有武装。As a cargobot's primary function is ostensibly to deliver government aid drops, 它会飞到信号中继塔附近，自行选择合适的场地投下补给然后离开。
Cargobots also play a vital role in the late-game activation of the nuclear missile silos hidden around Appalachia. Cargobots, when tracked during the "Hide and Seek and Destroy" repeatable quest, will spawn into the world transporting an airdrop that contains loot and a nuclear keycard; however, the cargobots can be shot down by anyone, including those who do not have the quest active. This nuclear keycard is necessary to attempt a launch at any of the three nuclear missile silos. To access this cargo, the player character must destroy the robot. When attacked, the bot will become "hostile" but unable to attack the player character. The cargobot will remain in (relative) proximity of the player character and high up in the air. Once defeated, the airdrop that the cargobot drops will have a single nuclear keycard inside. This airdrop will remain where it landed for five minutes before it self-destructs.