關於an overview of stimpak types in all games，參見Stimpak。
The super stimpak is a more advanced version of the regular stimpak found in Fallout: New Vegas. While it heals more severe wounds, it also has unpleasant side effects. The super version comes in a hypodermic needle, but with an additional vial containing more powerful drugs than the basic model and a leather belt to strap the needle to the injured limb.
In addition to healing, the game also adds the debuff "stimpak sickness" which happens after using a super stimpak. The effects are -1 to Strength and -1 to Agility and its duration lasts for 3–4 minutes. It cannot be cured by Fixer but can be fixed with Buffout. It is very problematic, especially in combat, as it may cause the player character to become overencumbered, and therefore slower in a critical situation.
Medicine skill effect
+72 Hit Points
+84 Hit Points
+96 Hit Points
+108 Hit Points
+120 Hit Points
+132 Hit Points
+144 Hit Points
+156 Hit Points
+168 Hit Points
+180 Hit Points
Note: Strength is not affected by Medicine skill level.
Note: Agility is not affected by Medicine skill level.
Two on a shelf on the main platform of the Violet and Violetta trailer compound, due west of Vault 3.
Most doctors in the wasteland have one or two for sale.
Three super stimpaks can be obtained in the Mercenary Pack.
Sierra Madre vending machine - Can be purchased in the Sierra Madre itself or at the Abandoned Brotherhood of Steel bunker, after finding the super stimpak vending machine code.
X-13 research facility - In the nightstalker test area of the facility. Shooting the forcefield in the ceiling of the small room with the strange still with an upgradedsonic emitter will drop a super stimpak into the room.