Salem was previously a quaint coastal town and seaport, 最出名的事件就是1692年的巫审案。 小镇在战后也曾发展出市集，不过due to Gunner activity in the area, the Church of the Children of Atom worshiping a radioactive crater house down the road,和临近海边泛滥的泥沼蟹侵占了这个地方，赶走了大部分人，只留下塞勒姆地区志愿民兵队的指挥官路克一人仍然坚守在这里。
Most of Salem's buildings are in ruins but a couple of them are still points of interest :
- 迷你核彈 - 在鐘樓的終端機底下。
- Fat Man - On the store shelf on the second floor of the boarded-up shop. One of Barney's turrets is also located here.
- The Devil's Due - The Sole Survivor will find the remnants of the deathclaw eggs poaching party. The quest starts by exploring the Museum of Witchcraft.
- Gun Run - Barney Rook asks the Sole Survivor to reactivate 5 turrets located throughout the town. The reward is Reba II, a unique hunting rifle that does +50% damage against bugs. The quest happens in the neighborhood of the Rook family house.
After completing the Gun Run quest for Barney Rook, the turrets will be hostile against vertibirds called in by the Sole Survivor.
Salem is first mentioned in the Fallout 3 add-on Mothership Zeta. It later appears in Fallout 4, as a location the player character can visit. In Fallout Shelter, it is mentioned only as a question in the weekly quest Game Show Gauntlet.
- Salem was originally going to feature a questline involving children who gained magic powers through mutations. They would be prosecuted by people from the town of Danvers, who viewed them as witches. The magic users were given spells from The Elder Scrolls V: Skyrim to use, but then, said spells were removed from the engine, causing technical difficulties. Danvers was also cut from the game due to being too close to Salem, leading to the quest being cut and replaced by the quest The Devil's Due.