In Fallout 3, if the Lone Wanderer says they hate their Pip-Boy and asks how to get it off, Stanley Armstrong says it's impossible. However, Doc Mitchell took his off somehow and it is possible in Mick and Ralph's store to swap it out for the Pimp-Boy 3 Billion after resolving Mick's problem.
If during the tag skill segment where you tell the first thing that comes to mind you choose immoral or otherwise evil answers, Doc Mitchell will imply that he finds you unsettling, and say that your moral standing makes sense for the position you are/were in.
While using the Vit-o-matic Vigor Tester, clicking on the up/down arrows to increase or decrease a statistic, or the left/right arrows to shift between statistics, may not work. If this happens, it may be that the game thinks that the arrow is somewhere else, in which case clicking elsewhere on the screen will produce the desired result. Another workaround is to use your keyboard's arrow keys (NOT the wsad keys) to increase/decrease statistics and shift between statistics.
If you start to use console commands, the game will completely freeze and when reloaded it will restart. Do not use console commands for this mission at any time.
After gaining the ability to move, you might walk slowly and not be able to sit. Just restart the system and make a new save to fix this.