在2274年時，麥奎迪走進了鎮長的辦公室，這時候距離公主宣布她的規則還不到五分鐘。根據薩米的說法，當公主要求將鎮長的頭銜改變為「公主」的時候，麥奎迪一拳打在了她的鼻子上，斥責她說燈火小鎮需要的是一個領導者，而不是一個公主。在那之後，他被選為了燈火小鎮的鎮長。The child mayor makes regular patrols around the underground settlement, keeping outsiders and potential trouble makers under close surveillance.
他在槍手工作了一段時間，但最終他離開槍手。在那之後，麥奎迪因為在槍手的地盤接活而被他們追殺。他熟練地使用他的步槍，並且往往能一擊爆頭。當僅存者在第三軌酒館遇見他的時候，他正在和兩個槍手談話，在他們離開後，僅存者可以用250瓶蓋（可以被降低到200或100瓶蓋，取決於僅存者的錢包大小）的價格招募他。This will be given back to the Sole Survivor after completing one of the parts of his quest. 在和他成為好朋友，並完成了他的個人任務後，他會給予主角一個「一擊必殺」的特技，V.A.T.S模式下攻擊頭部的成功率提高20%。
MacCready for Action: This unmarked quest consists of convincing MacCready to join the Sole Survivor.
前路漫漫：麥奎迪會要求主角幫助他解決那兩個一直騷擾他的槍手，在那之後，他會請求主角幫助他找到治癒他兒子的方法。NOTE: MacCready's affection gains will cap at 499 (stopping just short of "MacCready likes you") until the Gunners portion of this quest is completed.
He will steal when commanded to do so by the Sole Survivor. He is able to steal items undetected right in front of people.
If the player character attempts to steal from the VIP room of the Third Rail and gets caught, MacCready will leave their company and become hostile, prompting an interface for the player to send MacCready to a settlement, similar to Preston Garvey if the player kills a settler. If the player doesn't get caught, MacCready will like the theft.
If the player commands him to steal an item, or does anything to cause hostility while in Goodneighbor, MacCready will leave the Sole Survivor's company and become hostile, prompting an interface to send MacCready to a settlement.
MacCready can be acquired at the shop by any player character that has Charisma. When shopping with him as the active companion, the player character can exhaust him in order to buy any items from the asset deck's discard pile.
When the player character performs the camp action, he will become unexhausted. However, if the player character does not have eight or more bottle caps at this time, he must be discarded.
在特殊包裹這一任務中，和傑克·卡伯特對話時麥奎迪會暗示他相信外星人的存在，以及這真的令他毛骨悚然。這或許是暗示輻射3中關於Z星人的DLC。This may also hint that he is fascinated with space and/or science fiction, considering in Nuka-World's quest Trip to the Stars, he likes riding in the UFO ride.
If taken to the Boston Public Library, he will state that lions scare children in a horrified voice, a reference to his childhood character in Fallout 3.
Upon reaching Mahkra Fishpacking MacCready will mention that fish gives him terrible flatulence.
MacCready hints a case of severe depression throughout Fallout 4, such as when he tells the Sole Survivor that he thought it would've been better if he and Duncan died with Lucy, and upon romancing him, he mentions that they have saved him from himself. This could also hint he's had thoughts of suicide.
In concept art, MacCready is misspelled as McReady.
In idle dialogue or when selecting "Thoughts?" when speaking to him, he might say "I gotta be honest with you, I'd feel more comfortable with a rocky ceiling above my head," a reference to Little Lamplight.
Some of MacCready's dialogue hints that he gets motion sickness, further evidenced by his commentary by the sea, or upon boarding a Vertibird.
MacCready has the tendency to break out idioms and puns, upon commentary depending on location.
The fact that MacCready likes it when the Sole Survivor keeps the cure for themselves instead of giving it to Austin Engill in Hole in the Wall is inconsistent with his character, as he likes it when the Survivor helps children and parents. This may either be a bug or a hiccup with affinity design.
Contrary to MacCready stating his lack of knowledge with science, he does have a decent amount of knowledge with biology. Examples include commentary about not having his tetanus vaccination at Rocky Narrows Park and that he is aware that a deathclaw is a mutated Jackson's Chameleon.
MacCready will hum a tune and state that Diamond City Radio songs tend to get into his head. He hums the bass clarinet line for Easy Living from Billie Holiday, a song included.
In cut voice files, MacCready mentions a transmitter, most likely tasking the Sole Survivor to retrieve one. In one voice file he mentions contacting outside sources to aid the Sole Survivor.
If Dogmeat is present alongside MacCready as a companion through use of mods, while he will not like or dislike the player healing him while he's around, he will comment, "Take care of him, and he'll take care of you."
Tommy of Combat Zone once asked MacCready to fight in the ring, MacCready declined, a decision he seems to regret.
Companions such as Strong and Hancock will comment on MacCready's combat prowess. Strong states that he is a good fighter, almost as good as himself. Coincidentally, MacCready has the highest END stat among the human and Gen 3 companions.verification overdue, remove
Although MacCready likes declining Paladin Danse's offer to join the Brotherhood of Steel and dislikes accepting it, his dialogue reaction to each decision seems to imply the opposite.
pc Mayor MacCready is prone to disappearing. He tends to wander into obscure and dark corners. He may appear near the front gate if going outside and fast travel back to town, or standing on the platform where he first stood when he let the Lone Wanderer into town. One can move to his current position with the console command player.moveto 0000313b.
pc Sometimes MacCready will not give the option to open the gate, even if one is at that point and have followed the advice outlined in this wiki. One way to make sure that this does not befall the player is to click all of the grayed out speech options when speaking to MacCready. The dialogue option to open the gate comes after a line that is often grayed/dimmed. 表达式错误：未预料的<操作符
pc It's possible for MacCready to not open the gate after being instructed to do so. He will run to it, and climb up to the catwalk but will not activate the switch to raise the gate. This is because the scripted sequence requires Princess to be on the other end, and she may not run with MacCready to perform this function. Short of using the console to activate the gate/toggle clipping, the solutions are to use the other entrance, reload from a previous save, or attempt to move Princess in range of the event with the console command prid 000185d5 followed by moveto player. 表达式错误：未预料的<操作符
pc Doing DLC quests before opening the path will end "Picking Up the Trail" resulting in MacCready's and Joseph's dialogue options to vanish and making entry into Vault 87 impossible. The only solution is to resort to a save that still has "Picking Up the Trail" as an active quest, and redo whatever progress has been lost or to use the console command ResetQuest 00014e8c and go to the Citadel to start the quest again. 表达式错误：未预料的<操作符
pc Sometimes you may not be able to talk to MacCready or open up his inventory. He also fails to follow the player during fast travel. Entering the console command prid 0002a8a7 followed by moveto player will bring MacCready to the player, but does not correct the issue. 表达式错误：未预料的<操作符
pc After dismissing MacCready, hiring him again will prompt up the dialogue when you meet him for the first time, needing to be paid before being hired. Reloading a previous save fixes this. 表达式错误：未预料的<操作符