Reduces poison damage by this amount.Fallout game description

Poison Resistance is derived statistic in Fallout, Fallout 2, Fallout 3, Fallout: New Vegas and Fallout Tactics. It is also a rare resistance in Fallout 4.

This statistic reduces poison damage by a percentage as well as the chance to get poisoned. In Fallout 3 and Fallout: New Vegas, this statistic is hidden.

Fallout, Fallout 2, Fallout Tactics

  • The Fast Metabolism trait sets initial poison resistance to 0.
  • The Snakeater perk increases poison resistance by 25% per rank.
  • The Vault City Inoculations perk increases poison resistance by 10%.

Fallout 3

Poison Resistance is also present in Fallout 3. It has a much smaller part than in the previous games since only a few enemies (Radscorpions chief among them) use poison, and poison effects tend to be weak.

Example: A starting Endurance of 5.

  • The Cyborg perk can increase resistance by +10%.
  • The Survival Expert perk can add between an additional +2% to +6%.

Fallout: New Vegas

Fallout: New Vegas uses the same equation as Fallout 3, but Poison Resistance has much more use: there are cazadores, bark scorpions, night stalkers, and weapon poisons, all in addition to radscorpions. In Lonesome Road, there are also venomous tunnelers. Moreover, poison in Fallout: New Vegas is generally much more lethal.

Honest Hearts perks

  • Tribal Wisdom increases the poison resistance by 25%.

Old World Blues perks

  • Mile in Their Shoes - after consuming the nightstalker squeezin's, poison resistance is increased by 5%.
  • Cardiac Arrest increases poison resistance by 50%.
  • Heartless makes the player character immune to poisoning.

Items and consumables

  • Gecko-backed leather armor, Gecko-backed metal armor and variants (+15)
  • Wasteland tequila (+5, affected by survival) and Large wasteland tequila
  • Snakebite tourniquet cures poison and +85 resistance (30s)
  • Antivenom, Datura antivenom and Fiery purgative cure poisoning.
  • Hazmat suit (+85 resistance)
  • Blood Shield (+50 up to +85 depending on the player character's Medicine)

Fallout 4

Poison Resistance is not a derived statistic in Fallout 4. Acquiring it is only possible via three methods:

  • Astoundingly Awesome Tales #5: Grants +5 Poison Resistance.
  • Legendary Armor pieces with the Poisoner's modifier: Grants +25 Poison Resistance. A maximum of 5 pieces can be worn at once, totaling +125 Poison Resistance
  • Med-X: Temporarily provides +250 Poison Resistance
  • Creation Club Tunnel Snakes outfit: Grants +10 Poison Resistance.

Only a handful of enemies deal poison damage, such as the mirelurk queen and bloodbugs.