生化犬 - dogs with at least a mechanical part and an organic part. Their physical and mental abilities have been modified robotically and cybernetically, creating a kind of canine-robot hybrid. Unique models include Gabe (enhanced with a huge intake of psycho) and K-9 (with enhancements to the brain and vocal organs). Notable cyberdogs include Robodog (pet of Dr. Henry), Rex (pet of The King) and Roxie (temporary companion of the Courier).
腦控機器人 - robots that use the brains of criminals or chimpanzees suspended in bio med gel as their central processing unit. Unique model include Masterbrain (control robobrain of the Vault-Tec Headquarters) and Skynet (advanced AI system). Notable robobrain include Super-Ego (powerful robobrain in Big MT).
法蘭克·荷瑞根Frank Horrigan - fused to a modified version of Enclave power armor specifically made to encapsulate Horrigan's bulk, Horrigan cannot separate from his power armor as it acts as life support keeping him alive by pumping him full of drugs.
羅伯特·豪斯 - kept alive for over two hundred years by a life support chamber, House controls the computers and PDQ-88b Securitrons through cerebral implants. Notably, House has enhancements to pump food into his stomach, an enhancement around his heart that most likely acts as a pacemaker, and a waste pump around his crotch.
Dead Money克里斯汀·羅伊斯 - forcefully implanted in the Big MT, Christine has had several cybernetic modifications to her brain allowing her to do complicated equations and math with more ease, but problems during surgery have affected parts of her brain such as the Broca's area and primary visual cortex causing problems comprehending reading and being unable to write properly.
Old World Blues (add-on)智囊團 - a special type of brain bot. It consists of a robotic chassis housing a human brain with three monitors coming down from the main body, two monitors depict eyes and one beneath them a mouth.
Old World Blues (add-on)信使 - The Courier becomes a cyborg after their visit to Big MT. Their brain, heart, and spine have been removed and replaced by high-tech artificial mock-ups of the organs adding durability to the Courier.
B1000 - a unique cybernetic brahmin covered with living brahmin tissue over a metal T-bone.
Calculator - the controller and Overseer of Vault 0, composed of several human brains.
Dos - a Brotherhood Knight and a potential recruit having mechanically improved vision and cybernetic implants in his hands. He is always looking for new ways to tweak his body.
Reavers - the reavers are technologically strong in cybernetics enhancements and surgical augmentations, often use for their body, mostly scanning sensor that allow at least to sweep an area of twenty feet, detecting even a person who is sneaking. They are also known to use enhanced eye sight, hand surgical implants, central processors and valve-tube augmentation.
Simon Barnaky - after being kidnapped by the Calculator, Simon Barnaky became a unique humanoid brain bot. It consists of a large humanoid robotic suit equipped with a cannon on its left arm that a combination of a .50 machine gun and a missile launcher as well as a large claw on its right arm for close combat housing a human brain connected to a robotic program.