The drink has several minor uses for quests and items in Fallout 2. One of the three ingredients of a super stimpak as crafted by the artiste of the test tube known as Myron. Also, the Chosen One can use any sort of status-modifying drug to trigger a fatal heart attack in Big Jesus Mordino.
Shops in Klamath and the respective machines. The bottles can be obtained from vending machines by left-clicking on a Nuka-Cola machine and dragging the mouse to access the backpack and putting coins in the slot.
Nuka-Cola machines, other than for reasons of gameplay, restock every one to seven weeks. In Fallout Tactics, there is a special encounter with a man pedaling a bicycle cart. This is Phil, the Nuka-Cola dude, who claims via bubble text to be personally responsible for restocking the vending machines of the wasteland. An unlimited quantity of Nuka-Cola can be purchased in the Broken Hills bar (this may be explained indirectly by the Homebrewed Nuka-Cola recipe in Fallout: New Vegas).