A minigun is a multi-barrel machine gun with a high rate of fire, employing Gatling-style rotating barrels. It was a standard military weapon before the Great War, with Rockwell's CZ series being the most popular choice in the United States.
罗克韦尔CZ53是一种多管的高射速武器，六根枪管在马达的驱动下能以1000发/秒的射速将5mm弹头倾泻到敌人身上， with an ammo capacity of 120x 5mm round.因此5mm弹头本身杀伤力相对较低的这个遗憾完全地被射速弥补了过来。它那庞大的体形，以及运作时马达发出的独特声响，都足以使挡在它面前的敌人立刻四散奔逃寻找躲藏之所。这是一把理想的火力压制武器，敌人會难以对付正在包抄他们侧翼的我军。不过，當大战开始，CZ53已經略显老态，并且已经开始被更新型的CZ57“复仇者”机枪所取代。Later models of the CZ53旋轉机枪使用弹链拱弹，在通常情况下，弹链会被装在120发或是240发的弹链箱中直接和枪体钩挂在一起，並結合使用背负式的弹链箱。<section begin="CZ53" />The first model was the favorite weapon of the Mariposa super mutants during the Unity's time, and allowed most or all of the super mutants to wield them effectively with only one arm.<section end="CZ53" />
它是一把來自生化狗, except instead of a robotic body in the image of a canine companion, 把一条狗的活体大脑取出放在这把武器的维生罐里，使用.357弹药。Its "canine" features include 武器上部两个金属制的耳朵that move like a real dog's, 以及一个嗅觉传感器在维生罐上，以其嗅觉的敏感来探测目标。金属耳朵在武器对准目标的时候会兴奋地上下抖动。
A variant model of the regular CZ57 Avenger minigun seen in the Midwest which is more compact, completely black, less powerful and chambered for 5.56mm bullets with an ammo capacity of 120x 5.56mm round.
A variant model of the regular Vindicator minigun seen in the Midwest with a completely new design, a display screen that show the remaining ammunition and chambered in 7.62mm bullets with an ammo capacity of 100x 7.62mm round.
An extremely rare minigun, the MEC Gauss minigun was designed by the Chinese. Atypical for an automatic weapon, it uses Gauss technology, multiple electromagnetic fields to firing 2mm ammunition at over 90,000 rounds per minute to relativistic velocities, with an ammo capacity of 80x 2mm round.
<section begin="Vault-Tec 9mm minigun" />
A post-War minigun designed by Vault-Tec in the Secret Vault. The Vault-Tec minigun has a lower rate of fire than a general minigun but, unusually for a minigun, chambered in common handgun ammo. It has five barrels and it was used by the Attis army in Texas.
<section end="Vault-Tec 9mm minigun" />