|關於an overview of all weapons in the Fallout world，參見Weapon。|
A hand grenade is a thrown weapon that appears in all of the Fallout games. Most contain explosives designed to inflict damage in a wide blast radius by the fragmentation of their outer cases. Other types of grenades are used to disperse chemical or gas agents, ignite targets or materiel, cause electromagnetic pulse waves, release clouds of ionized plasma, stun targets with bright flashes of light and/or loud sound or create smoke as a means of concealment. Due to their varied nature, different grenade models may be more effective against some targets, and less effective against others.
Chemical gas grenades utilize some form of chemical reaction or chemical gas agent, like poison gasses, chemical smoke or intense heat and flames, to deliver their intended purpose.
Electromagnetic pulse, or EMP, hand grenades create a powerful magnetic field that induces high currents or voltages in the effected radius, damaging electrical circuits or disruption their function.
Fragmentation grenades are small hand-thrown bombs. 內含高爆炸藥，它的金屬外殼在爆炸時會產生許多小塊的碎片造成殺傷。
Nuclear grenades produce a very low yield nuclear explosion when detonated. Due to the size of the blast, great care must be taken to avoid injury when utilizing this type of grenade.
As its name would imply, the mini-nuke grenade is all the power of a mini nuke, packed into a hand-held explosive device. Only one exists in the entirety of the game.
電漿手榴彈通过瞬间产生大量等离子气体，rather than the typical explosion propelling fragments of normal hand grenades.