|關於an overview of brass knuckles in the Fallout series of games，參見brass knuckles。|
A simple, low-level, unarmed weapon in Fallout 3. These are quickly replaced with the more superior and equally common spiked knuckles or can simply be carried for weaker enemies, (such as radroaches, mole rats, etc.), for those who don't wish to expend ammunition.
Brass knuckles can successfully strike about 667 times from full condition before breaking.
- Steel knuckles - Slightly stronger than the regular brass knuckles, the steel knuckles only use 14 AP per V.A.T.S. swing.
- Spiked knuckles - a variant of knuckles with spikes affixed.
- Plunkett's Valid Points - a unique variant of spiked knuckles found on Plunkett.
Because spiked knuckels are not much harder to find, brass knuckles can be rendered obsolete as a weapon rather quickly. However, they are a great repair tool.