The knife is a small melee weapon that deals a moderate amount of damage, but characters start with better melee weapons in Fallout 2. Initially, it can serve as a somewhat valuable loot item, making it a helpful find. It is also very good in the beginning of the game against rats and other small animals, like geckos.
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Fallout[]
The Vault Dweller starts with one knife when they leave Vault 13, and Ed the skeleton carries one as well.