Harpers Ferry was occupied by the Free States in 2079 in an effort to turn the town into a major hub. By 2084, the town was prospering, serving as an important base in the Mire. The city was attacked by the Scorched in 2096. The Free States were unprepared for the devastation it brought and were driven back to their bunkers, trying to craft a solution to the new threat. A single robot vendor is all that is left of the Free States' effort.
At the outskirts of the town is an armory aligned with the Free States. The town itself is encircled by a wall made from scrap with several container box gates. A dominant feature of the town is a church with several workbenches.
The river to the northeast of town can be crossed by using a railroad/highway bridge which leads into a tunnel. However, the tunnel has evidently caved in; one cannot pass through it to the other side. The tunnel contains highly radioactive containers and a railroad car containing a sizable amount of loot. At the mouth of the tunnel is a wooden walkway leading under the bridge and to a path between the cliff and the water which leads to the ransacked bunker.
- 莉迪亞的日記第1頁 - 在城鎮最西部的637號房子旁邊的圓桌上。
- 莉迪亞的日記第4頁 - 在北門南邊的106號房子一樓，後門旁邊的金屬架上。
- 莉迪亞的日記第12頁 - 在城鎮西南部的398號房子屋頂上，就在南門旁邊，對面是診所。必須從394號房子的屋頂過去才能抵達。
- 莉迪亞的日記第20頁 - 在城鎮北門南邊的114號房子樓上。
- 莉迪亞的日記第24頁 - 在上述診所(126號房子)的二樓。
- 辭職信 - 同上。
- 安全避風港 - 上述114號房子的桌上。
- 保護自己人 - 城鎮東南部的軍械庫，南翼二樓的羅利的終端機旁。
- 恢復秩序 - 北門終端機旁。
- 艾拉的日誌：哈珀斯費里 - 在城鎮南部的教堂，裡面桌上。
- Harpers Ferry postcard - Obtained during the quest A Mark in the Past - Harpers Ferry.
- 雪倫的憤怒信件 - 教堂桌上。
- 傑德的信 - 上述位於軍械庫的保護自己人的隔壁房。
- 李奧納德的日記 - 診所隔壁棟樓上。
- 赫蘇斯·桑戴的全像卡帶（一） - 城鎮東南部的402號房子屋頂。
- 赫蘇斯·桑戴的全像卡帶（二） - 南門終端機旁。
- 防禦工事鑰匙 - 教堂中央的桌上。用來打開分布在城鎮林林種種的門。
- A significant number of chems in the basement of the clinic.
- Being followed - Note, in a cooler on the river northeast of Harpers Ferry.
- 每月案件紀錄，十月 - 上述的106號房子一樓。
Harpers Ferry appears only in Fallout 76.