- Override the containment lockdown.
到達麻州公路交流道時，溫洛克和巴恩斯都會在上頭的交流道上，因此需要找到附近的一個升降機; 通過快速旅行可以找到交流道以北的一台，節省時間。 交流道的火力非常大，有10-15名普通槍手，一名指揮官和一名突襲者。 他們中的任何一個也可能在更高級別使用一套T-60動力裝甲。 在溫洛克和巴恩斯被殺之後，麥奎迪會向唯一倖存者表示放心，看到這兩位因他離開槍手而騷擾他的傢伙被殺，並歸還了僅存者當初僱用他的瓶蓋。
在與麥奎迪的關係指數達到750之後，任務的第二部分才會開始。 麥奎迪將再次與唯一倖存者交談並說出他的兒子鄧肯，以及他是如何患有可能致其命的疾病。 然後他請求唯一倖存者前往邁科藥研，在那裡尋找解藥，並且他有containment override密碼。 在那裡，解藥位於較底層的地方，這需要到達設施頂層的執行終端以 override the containment。 這裡的敵人相當弱，只有狂屍鬼（包括一個發光種）散佈在裏頭。
- 請記住，有一個用來解鎖聖約村中的終端名為Jacob密碼。 如果在進入邁科藥研時，玩家的物品欄有這項東西，麥奎迪可能不會給玩家頂層的執行終端的密碼，要等到他抵達終端處。
- It is possible for MacCready to never give the password, if he's occupied/separated from the player when first reaching the terminal. This can be caused by MacCready falling through the hole in the floor to the lower level. To prevent this, save before heading near the executive room, and make sure to complete the fight without becoming separated from MacCready. Going back to the terminal later with MacCready will not result in receiving the password if this has occurred.
- Both issues can be resolved on PC by using the console command player.additem 001965f8 to add the correct password to your inventory.
- After you enter the sublevels and enter the room full of cells, it may seem impossible to proceed lower at first glance. There is, however, a ramp leading down through the floor in one of the cells (south side).
- Once he idolizes the Sole Survivor, MacCready will give them a wooden soldier toy as a token of his affection. This item will be automatically added to the Junk category instead of Misc, so care should be taken to not scrap it by accident if the player wishes to keep it.
- 如果向黛西提交解藥卻只有交易選項時，請確保麥奎迪位於黛西的商店中。麥奎迪在進入芳鄰鎮時會有進入沙盒狀態的傾向。 命令他站在黛西的櫃檯前可以解決此問題。
- 如果你在開始任務之前拿到了預防藥，可以在進入邁科藥研後，使用控制台輸入player.drop 4e700 1 將它放在麥奎迪前面再撿起來，任務就可以繼續進行下去。
- Has platform::Playstation 4 Winlock may be encountered in an inaccessible area, on top of the upper freeway platform, rendering the mission unable to complete. [已核实]
- Has platform::Playstation 4 Possible Fix: Move south, the player then can access the upper deck by a collapsed structure forming a ramp, and jumping a small gap from girder to girder to finally reach Winlock.
- Has platform::PC Having already cleared Mass Pike Interchange the quest may not start when bringing MacCready there.[已核实]
- Has platform::PC Winlock and Barnes may not be hostile to the player at Mass Pike Interchange, even after the player kills all of the other Gunners at that location. Even if the player kills either Winlock or Barnes, the other may not be hostile.[已核实]
- Has platform::PC MacCready will add the location of Med-Tek Research to the player's Pip-Boy. However when selecting 'Show On Map' for the quest objective 'Bring MacCready to Med-Tek Research' the map will not center on the location. There will also be no objective marker to direct the player to the location (this bug will not affect the quest's progression, once the Sole Survivor reaches Med-Tek Research it will progress to the next step of the quest).[已核实]
- Has platform::Playstation 4 "Locate the Executive Terminal" will sometimes not update when the player reaches the terminal. Which also means MacCready will not give the player the password. [已核实]
- Reloading to a previous save may fix this.
- Another possible fix is to use the console command SetStage COMMacCreadyQuest 160.
- Has platform::PC If the player picked up the Prevent even before making MacCready a companion, the easiest way to fix it is to do SetStage COMMacCreadyQuest 0; the Sole Survivor and MacCready will be partnered up, show him the Prevent, and take it back to Daisy. [已核实]
- Has platform::PC A glowing one inside the room with the Prevent can spawn or walk too close to the terminal and door, prohibiting interaction with the terminal to open the door even though there is an intervening wall - the game will go through the animation of aligning with the terminal and begin to zoom in, then suddenly abort and return player control. There are two possible solutions to this issue.[已核实]
- Reload from a save prior to entering the sub-level elevator and hope the offending ghoul doesn't trip the bug again.
- Open the command console, focus on the door, then disable it. After clearing out the ghouls, enable the door and use the terminal to open it as intended to also open the shortcut exit - if the door is still disabled, the open prompt will not appear on the terminal and the shortcut cannot be opened.