The city of Clarksburg, located in the northern region of Appalachia, was very much a functional city. It had a grocery store, a Post Office, a hardware store, a gun store, a church, and even a private shooting club. Unfortunately, like most of the region, it suffered from the man vs. robot riots and protesting that affected much of the rest of the state. The city was ultimately ruined after the Great War, when the Toxic Valley was polluted by industrial chemicals. Many of its citizens left for Morgantown, and those that stayed became sick from the toxic chemicals in the water. Eventually, the town's population was driven down to just three: Jill, Ande and Cooper Lu. Jill and Ande were soon killed by a yao guai, leaving Cooper alone. She decided to leave Clarksburg and search for survivors elsewhere.
The town of Clarksburg has many buildings along its central street, including a supermarket/pharmacy, a post office, a church, an ice cream parlor with a cooking station on the roof, a gun store with a weapons workbench and armory that can be unlocked via a level 2 terminal, a hardware store with an armor workbench, and a couple of decimated houses on the outskirts of town. The Clarksburg Shooting Club can also be found here.
- 瑪麗的日記頁 - 野餐驚魂任務期間於鎮上西北部半沉的拖車屋取得，在背包裡。
- 機密安全資料和重要備忘錄 - 懸案任務期間於郵局內的郵箱取得。
- 盧庫柏的日記 - 教堂對面的一棟兩層樓高房子，衣櫃底下。
- Raider power armor - Located on the fourth floor of the brick building on the east end of town. Accessed via the fire escape by taking the stairs behind the gun shop to the roof.
- Random armor plan - On the roof of the repair store, inside the room with a trunk, on a metal shelf.
- Random recipe - On the second floor of the pharmacy building, on a kitchen counter to the right of a box. Accessed by the stairs at the rear of the building.
- Fusion core - In the basement of the warehouse on the western end of town, inside the fusion generator.
- Chainsaw - Can spawn on a shelf inside the hardware store at the top balcony.
- Random weapon mod - Inside the gun shop on the second floor, on a desk.
雀爾西的日記頁 - 無法被撿起的筆記, in a house on the eastern side of town.
Clarksburg appears only in Fallout 76.
- 戲院粗略地還原了當地的Robinson Grand Performing Arts Center。One major difference is its lack of marquee in-game.
- 五金行和工廠粗略參考了當地的Standard Mill complex.