William was the husband of Sheila Brandice and the father of Will and Frank Brandice. Originally from Navarro, Brandice deserted from the Enclave for unknown reasons. He journeyed across the continent and settled in the town of Grayditch, as a doctor. Believing the Enclave was closing in on him, Brandice took to the underground, but wasn't ready for quite so many fire ants. A one-time friend of Fred Wilks, Brandice is said to have a small weapons cache saved from his transcontinental trek.
October 2, 2276: Brandice and his family arrive in Grayditch after having crossed the country from Navarro because he was trying to escape being captured by the Enclave, as he deserted them (having previously been an Enclave soldier/doctor).
October 30, 2276: He became concerned after scavenging a radio and hearing an Enclave broadcast recorded by John Henry Eden.
November 15, 2276: Dr. Lesko moved to Grayditch and offered Brandice caps to help build his shed, but Brandice declined.
February 24, 2277: He traveled to Megaton to buy a better gun because the fire ants were becoming more aggressive. It is hidden behind the refrigerator.