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Virgil's Cure is a miscellaneous quest in Fallout 4.

Quick walkthrough

Miscellaneous quest: Virgil's Cure
Quest starts automatically when speaking with Virgil during the main story quest The Glowing Sea.
Travel to The Institute.
Find and enter the Institute FEV lab.
Find and take the serum.
Return to Virgil at the Rocky cave.
Give Virgil the cure.
Tell Virgil you'll stop looking for the cure.
Convince Virgil there is no cure.
Return to see Virgil 3 days later.
Fight against Virgil.
Accept to end Virgil's life.
Rewards: Virgil returns to human form.
The Rocky cave is freely usable and lootable.
Reward: Virgil's rifle

Detailed walkthrough

Virgil's Cure automatically starts when talking to Brian Virgil in the main story quest The Glowing Sea. In the conversation the Sole Survivor first has with Virgil, he requests that they retrieve a serum in exchange for his information about the Institute. From this point, the quest cannot be advanced until the player character makes their way to the Institute later in the game.

When in the Institute, find the Institute FEV lab, an old locked area of Bioscience. There's a back entrance with a Master terminal in the main room of Bioscience. This leads directly to the room the serum is in and also the main entrance to the FEV lab, found at the end of some seemingly abandoned storage halls and rooms. Once in the FEV lab, travel through it to the end room, where the serum is located. The lab will be defended by several turrets and also an assaultron but is otherwise uninhabited. The serum is in the final room in a lab machine on top of a desk.

An alternative way into the FEV lab is via a Novice locked door. As soon as one enters the Bioscience division, turn right. Follow the corridor into a storage room. Turn right after the first rack. Then, after going through the door, take an immediate left. Go straight to the end door where one will find the Novice locked door.

Bring the serum back to Virgil. The player character has two options:

  • One can simply give Virgil the serum, and certain companions will react differently to this choice. For example, John Hancock, Piper, Nick Valentine, and Codsworth like the player character's choice to cure Virgil (Curie loves it), but Danse will not like it at all; this is due to what happened with his friend Cutler which resulted in a strong hate from Danse towards super mutants and other non-human creatures alike.[1] Strong also will not like it as he prefers being a super mutant and is angry with the doctor's ambitions to cure the others.
  • One can also lie to Virgil through a sequence of three speech checks (the difficulty of each one increases each time), claiming that the serum wasn't there. After the first two checks, the player character still has the option to give the serum to Virgil through breaking and re-initiating dialogue with him. After the third speech check Virgil requests that the player character kill him and the quest will fail. If the player character has visited Swan's Pond and read the notes there, they can ask Virgil if he remembers Edgar Swann after the first speech check. This will lead to a medium speech check to convince him to end his life (bypassing the hard check).

After giving the serum to Virgil, wait three days and return to find he has transformed back into a human. Speak with him again and he will offer the player character his lab for use, which will make all items therein available for looting.

Quest stages

31 Find Virgil's Serum
32 Bring the Serum to Virgil
60Quest finishedCheck on Virgil


  • The first stage of this quest is not listed under miscellaneous quests; only the last two stages are.
  • The quest requires Novice lockpicking and hacking skills only to get through the doors within the FEV lab, which itself is locked (Master) within the Bioscience dome of the Institute. This can be avoided however by going through some doors behind the main lab.


  • PCPC Playstation 4Playstation 4 Xbox OneXbox One Virgil may become hostile while one is wearing a X-01 power armor suit or a power armor helmet with the targeting HUD mod installed. [verified]
  • PCPC Playstation 4Playstation 4 Xbox OneXbox One This miscellaneous quest may not be given but if you return the cure without having the quest anyway, it may continue even though a marker was not given. [verified]
    • Alternatively, before acquiring the cure serum, you can return to Virgil and, when he asks if you have the serum, you say "what serum?" He will then remind you that you had a deal and the miscellaneous quest will be added.
  • PCPC Using the console to duplicate the experimental serum before completing the quest will result in it being uncompletable. As the option to give the serum to Virgil will have its text removed. Clicking that option anyway will result in either nothing happening or activate the cutscenes with no dialogue.[verified]



  1. The Sole Survivor: "Why do you hate Super Mutants so much?"
    Danse: "They're responsible for the death of a close friend, a Brotherhood Knight named Cutler."
    (Danse's dialogue)