The troubles of this facility started only a few months before the Great War. On September 29, 2077, Martin Reid began to uncover that not all was right with his employers. Spotting several odd shipments to the Vaults under their purview, he immediately took his discovery to his boss, Frank Davidson, who noted in his personal log two days later that the company wouldn't do anything of the sort. Then on October 7, he received word from Walter Scott that a shipment for Vault 111 was in the basement, marked "Vault 111 - DO NOT OPEN." When he opened the shipment, he discovered hundreds of gallons of liquid nitrogen. The shock from this obvious clue that all was not right at the company is what caused him to put in his two weeks notice on October 22.
In addition, Frank Davidson was a sociopath, once breaking a pool cue over Roger's head because he stood too close to the table when Mr. Davidson was taking his shot. In his personal log, he notes that when Sharon accidentally spilled coffee on his shirt (on October 13) he had a burning desire to stab her in the throat with his pen. He would eventually fulfill his murder fantasy on the 17th, and wrote that he had the same desire to "discipline" Mr. Reid for continually bringing up his Vault theory on the 19th.
The reception area with blocked stairs and an elevator to the right of the entrance. A few small rooms down a hall to the north with minor loot including a lunchbox. There is a collapsed floor in a kitchen leading up to the second floor. The building is inhabited by feral ghouls.
The second floor's entryway is on the north end with a pair of small offices. On the east side of the floor is a small theater room and Dr. Reid's office where one can see a bit of info about Vault-Tec's operations. On the south side is a bullpen-style office and stairs leading up.
On the east side of the third floor is a conference room. The middle of the floor is a game room with a pool table. The north has a large office with a terminal and an Advanced locked safe. There is also a basement that consists of a large warehouse area with a Novice locked terminal and an Expert locked back door.
The first floor elevator leads to the basement, where Walter Scott's terminal is found. There is a skeleton stuffed behind some crates under a shelf in the corner of the basement next to a pen. An Expert locked door leaving the basement can be unlocked with the terminal.
- Mini nuke - In the toilet in the basement inside the closet.
- Three Vault-Tec lunchboxes - One on the third floor on a desk in the back office, one on the first floor in the kitchenette and one on a shelf in the basement.
- Fusion core - On the roof of a building west of Vault-Tec Regional HQ. It can be accessed by climbing construction scaffolding and a fire escape (with one jump up from a skylight) on the building northwest of Vault-Tec Regional HQ's front entrance, then jumping down to the building northeast of the entrance.
- Quartermastery: Scribe Haylen has identified the location of a piece of technology she wishes to retrieve and catalog. She asks the Sole Survivor for help in bringing back the technology in one piece.
- Concierge: Mercer's new Railroad agent, Caretaker, needs help clearing a location so that he can make progress on helping a synth escape the Commonwealth.
- Cleansing the Commonwealth: Knight Rhys gives the Sole Survivor an assignment to clear the location of what he calls "abominations" to further the aims of the Brotherhood of Steel.
- Treasure Hunt: The Sole Survivor finds a note that suggests a large number of caps or chems may be stashed nearby.
- In the basement there is a skeleton wearing a lab coat stuffed behind some crates in the northeast corner of the room, most likely the remains of Sharon, as there is a pen next to the remains (mentioned in one of the terminals that Frank Davidson would stab her with a pen if she spilled coffee on him again), and it is mentioned she has been missing for a few days in a terminal entry nearby.
- On the third floor in the pool table room is a plastic pumpkin. Despite the fact that terminal entries indicate most of the former occupants of this office building seemed unaware of or shocked by the true nature of their employer, some rat poison can be found inside this pumpkin. It is—probably not coincidentally—located near Davidson's office.
- Terminal notes talk about shipping Jet to Vault 95, which was allegedly invented between Fallout and Fallout 2, by one of the potential companions in 2, Myron.
The Vault-Tec Regional HQ appears only in Fallout 4.
- Vault-Tec Regional HQ terminal entries; Dr. Reid's terminal, 09/29
- Vault-Tec Regional HQ terminal entries; Mr. Davidson's terminal, 10/02
- Vault-Tec Regional HQ terminal entries; Walter Scott's terminal, 10/15
- Vault-Tec Regional HQ terminal entries; Mr. Davidson's terminal, 10/13
- Vault-Tec Regional HQ terminal entries; Walter Scott's terminal, 10/19
- Vault-Tec Regional HQ terminal entries; Mr. Davidson's terminal, 10/19