The USS Interference was a submarine for the United States Navy.
In 2066, the U.S. Navy Missile Cruiser USS Ebon Atoll was accidentally sunk by the USS Interference during the Battle of Anchorage. The Interference mistook the Ebon Atoll for an enemy vessel and shot it with a nuclear torpedo, killing all on board. It was one of the worst U.S. Navy disasters since World War II.
The USS Interference is mentioned in Fallout 3.
- Museum of Technology plaque: This flag was recovered from the wreck of the U.S.S. Ebon Atoll, a U.S. Navy Missile Cruiser, sunk off the coast of Alaska in 2066 with all hands lost. The cutting edge vessel's loss was due to a nuclear torpedo strike from the U.S. Navy Submarine, the U.S.S. Interference during the Anchorage Campaign. The submarine mistook the cruiser for an enemy vessel during radio silence and sunk it before obtaining visual confirmation. This ranks as one of the most tragic disasters in U.S. Naval History since World War II.