Tin cans are sealed metal containers used to hold and preserve perishable food, such as Pork n' Beans. Their airtight seal allows food to keep for years, though all tin cans found are open, empty, and unlabeled. In-game, they are typically found either in places where food is or was once sold, such as grocery stores and gas stations or alongside camping grounds and hideouts.
- Tin cans are one of the components in crafting powder charges.
- With Gun Runners' Arsenal, they are used to craft Nuka-grenades and tin grenades.
- In the Dead Money add-on, they are used as a component for the Sierra Madre martini.
- Also in Dead Money, with the Junk Rounds perk, tin cans can be used along with scrap metal, and various cases and hulls to make "junk rounds." This requires five tin cans, one piece of scrap metal, and a case or hull for the ammunition desired.
- Tin cans are among the pieces of junk metal accepted by Isaac in the unmarked quest Dealing with Contreras for fulfilling the McCarran arms request.
The base game alone has 1,292 tin cans placed in the world, again not counting vendors, cans found in containers, or those found in add-ons.
- There is a large amount in Aerotech Office Park, especially in suite 200 where they cover the ground along with bent tin cans. There are exactly 74 bent tin cans and 57 regular tin cans.
- 44 cans are scattered around the Camp McCarran concourse near Cpl. Farber, who gives the unmarked quest Not Worth a Hill of Corn and Beans. However, all cans in the terminal are considered owned and must be stolen.
- There are eight or nine tin cans in the Allied Technologies offices along with several giant soldier- and worker ants.
- Heading east from the Allied Technologies Offices and entering the abandoned warehouse will reveal at least 18 on the shelves in the back of the room near the large storage containers.
- There are at least ten tin cans split between the Powder Ganger camp east and Powder Ganger camp west, they are spread across around the camps along with bent tin cans.
- There are five tin cans located in the Brotherhood of Steel safehouse, which can be accessed after gaining a liked reputation with the Brotherhood of Steel.
- There are ten tin cans located at the Mesquite Mountains camp site scattered around the fire pit and the picnic tables along with several bent tin cans.
- There are eight tin cans located at the tribal village around the campfire and may be covered by the bodies of the cazadores that inhabit the area.
- In Vault 3, home of the Fiends, there is a total of 42 tin cans scattered throughout. 26 of them are scattered about in the recreation area, with almost all in the halls. In the living quarters, there are 16 tin cans mostly located in the hallways.
- There are ten tin cans by the travel marker for the Goodsprings source. Four are located scattered around the campfire where Sunny Smiles teaches the Courier how to make healing powder and several yards away from the campfire next to a small camper with two beds are six more cans.
- Near Powder Ganger camp west there is a destroyed truck backed into a large radioactive pit, at the end of this truck there are four cans along with several milk bottles and bent tin cans.
- In the Bison Steve Hotel there are nine tin cans inside the locked storage room to the right of the main entrance. Four more can be found in the hotel's cafeteria where several of the convicts are located.
- At the NCR Correctional Facility there are five cans behind cell block B among the radioactive pools and other garbage. Two more can be found in the northeast corner guard tower. Two more can be found in the western guard tower closest to the visitors center.
- Six tin cans may be found at the Nipton Road reststop with two in the garage separate from the main building and four on the front porch of the store.
- 14 cans may be found in the fenced-in area of the Gibson scrap yard, nine found on the west side, stacked in a nice little pyramid, two near some locked metal boxes on some shelves, and three near a large, overturned dumpster in the northeast corner of the area.
- There are a few tin cans in the houses in Nelson, though they have to be stolen.
- There are some tin cans in broc flower cave near the Ratslayer.
- There are three tin cans to be found in Cannibal Johnson's cave.
- Old Lady Gibson may sometimes sell them.
- There are 35 tin cans at the Boulder Beach Campground and three more at Ranger Station Alpha nearby.
- Five tin cans can be found in the east pump station.
- There are ten tin cans in The Gray.
- Six tin cans can be found at the sniper's nest.
- Five tin cans can be found at the Great Khan armory.
- Six tin cans can be found at the north cistern and another six can be found at the south cistern.
- 20 tin cans can be found at Cottonwood Cove, not including any that may spawn in containers. There are eight in Cottonwood Cove shack, seven in the mess hall and five in the restrooms, three in the men's and two in the ladies' restroom.