Located on the shores of Spruce Knob Lake, this small campground once offered a place for hikers to rest and relax before returning to the trail. As of 2102, it is a mirelurks breeding ground, though it can also be inhabited by ticks and wolves. A small camp due north, at the base of the monorail pillar, may contain a random Vault-Tec bobblehead.
- Impromptu raider meeting - Holotape, on a table in a campsite near the water, next to a tent with a steamer trunk.
- Potential Vault-Tec bobblehead - By the cooking station and a tent, on a small green table.
- Potential recipe - By the cooking station and a tent, on a table
Spruce Knob campground appears only in Fallout 76.