As with all houses in Tranquility Lane, it has two stories with the front door entering into the lounge. On the ground level, there is also a bathroom and a kitchen. Upstairs, the house has another bathroom, a study, and a bedroom with a queen sized bed with lacy underwear laid out on the mattress.
- The Simpson residence contains one special item that can be interacted with to complete Betty's tasks, namely the lacy underwear.
- As with all houses in Tranquility Lane, the Simpson residence looks untouched by the war.
Simpson residence appears only in Fallout 3.