“Your spouse is no longer with you. I hope you're happy.”— Fallout 2 description
Separated is a reputation title in Fallout 2.
To get this title, the Married title is required and the spouse is either dead, sold into slavery or divorced.
Davin or Miria disappear forever and talking to Grisham about it gives him a heart attack.
Father Tully in New Reno's Drunk Cupid Chapel can offer divorce, in exchange for one bottle of alcohol.