These secretaries create and file records of the actions taken by Littlehorn & Associates on the East Coast. Although they have to work hard, they are all glad to have gainful employment under Daniel Littlehorn.[Non-game 1]
When trying to interact with them, they will say that they're busy and don't have time to talk.
Should the Lone Wanderer kill one of the secretaries, neither Daniel Littlehorn nor the other secretaries will turn hostile. They will only exclaim, "Better her than me!" or, "Good riddance!" and move on with their tasks.
↑Fallout 3 Official Game Guide Game of the Year Edition p.82: "Littlehorn Secretary: Furiously typing and thankful to have a gainful employment with Littlehorn and Associates, the four secretaries spend their time creating and filing records of all associates' activities across the East Coast. As life is cheap, hard work is expected, not rewarded.""