Second Street contains the following locations:
- Golden Globes (owned by the Corsican Brothers)
- Jungle Gym (owned by Stuart Little)
- Salvatore's Bar (owned by Louis Salvatore)
- Shark Club (owned by John Bishop)
Second Street connects to Virgin Street, to the south.
- Become a Porn Star: The Corsican Brothers are looking for a porn star, but the Salvatores are looking for the brothers because of the late payment.
- Become a Prizefighter: The Jungle Gym is looking for fighters for the ring.
- Louis Salvatore: Needs assistance with a task requiring the circumvention of Mason.
Second Street appears only in Fallout 2.