Aside from the threat of multiple giant radscorpions, a pack of night stalkers roam nearby. The two creature types normally attack each other, but if the Courier is detected, they'll attack the Courier instead.
Inside is a long corridor that leads to a large double-room cavern containing five radscorpions and a radscorpion queen. At the beginning of the corridor, a dead wastelander can be found. In the first room, there are two other dead wastelanders and in the last room, that contains the radscorpion queen, a dead Jackal gang member and a dead prospector can be found. After 144 in-game hours (not 6 days, calculated "the next day" at 12:00 A.M.), seven radscorpions will re-spawn (2 medium 50% chance, 1 medium 75% chance, 2 small 30% chance, 1 small 50% chance, 1 small 75% chance, unique random encounter).
Sometimes a wastelander can be found upon entering the burrow. He'll stay still near the entrance.
The scorpion burrow appears only in Fallout: New Vegas.