After completing the quest Left My Heart, she, along with her mother and brother, will run to the Old Mormon Fort within Freeside.
If her mother dies in the escape from Cottonwood Cove, she will mention it if you talk to her at the Old Mormon Fort. She will not mention her brother's death, should he die in the escape.
Killing her mother or brother by detonating their collars will result in her becoming sad and dismissive, no longer allowing her collar to be removed. She can still be freed after paying Canyon Runner but says the player character will get no thanks from her.
PC When arriving in Cottonwood Cove, Sammy may already be dead (she spawned in the lake and her collar activated). If she is dead, Kenny will not give you an option to deactivate his collar, instead calling you a "killer"." To rectify this and complete the mission find Sammy's body and resurrect her inside the slave pen, this will allow you to speak to all the Weather's family and deactivate/activate their collars.[verified]
PCXbox 360 When arriving in Cottonwood Cove or loading a previous save in the area, Sammy may be standing or walking outside the cage. She will exhibit the same behavior as though she was in the cage and will walk into the cage when the gate is opened.[verified]