He led the Justice Bloc and many vault residents in a bloody civil war over Overseer Order 745, which threatened the Justice Bloc's hold over the vault. He may have died during these riots, as although he is heard on the Justice Bloc HQ security recording, he is not heard on the Vault 11 entrance log.
Although not included in the final version, at one point Roy Gottlieb was to appear "in the flesh" in Fallout: New Vegas. It is unclear what expanded role, if any, he was to serve.