Rose's syringer is a unique ranged weapon in Fallout 76.


During the Flavors of Mayhem quest, Rose requires the player character to shoot the syringer at an enemy, with the intention that the player character hide during the 60 seconds that the enemy is temporary buffed, and then easily killing the enemy while it is weakened during the subsequent 60 second period. This weapon will not work on robots; use it only enemies that are "flesh and blood."

However, this weapon is equally effective with other teammates to give them a temporary buff for 1 minute, with the understanding that during the subsequent minute they will temporarily become more vulnerable to enemy attacks.

Karma syringe details
  • +25 DR, ER and RR for 30 seconds
  • +15% damage for 30 seconds
  • +50 max hp for 30 seconds
  • Does not work on Essential NPCs, SBQ, Wendigo Colossus or any Robot/Turret
  • There is no debuff

Weapon modifications

ModDescriptionNamingDamage changeFire rate changeRange changeAccuracy changeAmmo capacity changeAP cost changeWeight changeValue changeRequiredComponentsForm ID
Karma syringe barrelMakes the target incredible powerful for 60 Seconds, but incredibly weak for 60 Seconds when it wears off.+120+7+0.5+33Firecracker berry x2
Glowing resin x1
Psycho x1
Steel x1




  • If the mod is applied to another syringer (not Rose's Syringer) Rose will not recognize the mod and the quest can not be advanced. While the incorrect Syringer can be scrapped, scrapping the modified item does not recover the karma mod
  • The buff effect only lasts 30 seconds and there is no debuff period after it wears off.

Community content is available under CC-BY-SA unless otherwise noted.