Poison is an item found and used throughout Fallout: New Vegas.
It can be applied to either unarmed, melee weapons, or thrown melee weapons, and takes effect on the next entity to be attacked with the poisoned weapon. The poison is applied to a melee or throwing weapon by equipping the weapon and "consuming" the poison. The poison will then be taken out of the one's inventory and then added to the weapon. Besides finding poisons, different types of poisons can also be crafted at a campfire, provided the character's Survival skill is high enough. Killing NPCs by the poison effect will not affect the player character's faction reputation.