Nuka-Cola was invented in 2044 by John-Caleb Bradberton. Its unique taste gained widespread popularity, quickly becoming the most popular soft drink in the United States with an extremely dedicated following. The widely known dazzling blue bottle color was adopted as standard in 2052, after market research programs indicated that the blue color was the favorite in 86 people out of 100 polled.
The ingredients of Nuka-Cola include: carbonated water, caramel color, aspartame, phosphoric acid, potassium benzoate (to protect taste), natural flavors, citric acid, and caffeine. What gives it a unique flavor is the essence of seventeen different fruits mixed in just the right proportion to give the beverage its trademark taste. Some versions of the drink also include vita-minerals and health tonics. During the Great Passion Fruit Famine of 2044, people actually noticed the taste difference when the recipe was changed.
The new Nuka-Cola has a circular label, unlike in previous games. Additionally, the design of the bottle as a whole has changed, now having a pronounced "belly" with "fins" at the bottom and generally evoking the shape of a rocket or nuke. A loading screen explains that the new shape was adopted due to a patent infringement lawsuit made by an unknown rival company that supposedly claimed the original shape of Nuka-Cola bottles first.
Nuka-Cola caps seen throughout the game either in advertisements, memorabilia, or as actual collectible caps such as those thrown out by the bottlecap mine have the classic Nuka-Cola logo on them, but this logo is missing on the cap of the bottled Nuka-Cola item, which is simply plain red.
During the pre-War section of the game, Nuka-Cola can be interacted with, causing the player character to say something about them, but cannot be taken.
Nuka-Cola floats are a beverage made by using Nuka-Cola, as suggested by a sign in Concord.
Nuka-Cola can be put into Buddy through the "I'll take a beer" dialog option to produce ice cold Nuka-Cola 12 hours later.