There are several houses available for the player character to explore. The house with the sandbags in front of it is heavily booby-trapped. Inside, one can find are frag mines in the corner of the living room, kitchen, and bathroom. Both doorways conceal shotgun traps. There is a cage with three bark scorpions directly inside the house.
There is an Easy locked safe with a grenade rifle inside, but if the pressure plate to the front of it is triggered, the scorpions will be released. The Average locked cabinet in the kitchen contains some provisions, as well as a dead Legion recruit with a machete, armor, and helmet. A campfire can be found in the Good Luck trailer park, located on the southmost end of town.
In the house to the southeast of the town hall, a prototype Mister Gutsy can be found. The terminal in the house states that the previous owner had two, but only one is found. The house contains a few damaged weapons, including two .357 Magnum revolvers, a plasma pistol, a laser rifle. The house also has various metal/electronic parts and items needed for weapon repair kits, including wrenches, scrap metal, wonderglue, and duct tape.
- A note titled Declaration of Vital Essence - Inside the heavily booby-trapped Nipton home with sandbags lined up in front of it, directly east of Nipton General Store. This note can be found in the tool cabinet in the kitchen.
- Sunset Sarsaparilla star bottle cap - In the wooden house directly south of Nipton General Store, on the bookshelf next to the Sunset Sarsaparilla bottle in the bedroom.
- A larger than usual red plate - On the table right after entering one of the Nipton Houses. Taking the plate and dropping it once will keep it the same unusual size, but picking it up and dropping it again will cause it to become a normal-sized red plate.
The Nipton houses appear only in Fallout: New Vegas.