On the "Pentagon Library terminal" in the Citadel, it can be discovered that the mole rats in the Capital Wasteland (and possibly the other mutated rats in the West Coast and the Core Region) are the result of an American government program (codenamed 'CLOACINA') to develop an invasive lifeform that could be planted in China, where its aggression and fast breeding would help undermine the Chinese war effort. It is noted that a genetic 'kill switch' was included to help the US Army clean up the rats after the theoretical fall of China. Additionally, it is revealed that the researchers attempted to use the Forced Evolutionary Virus to further augment their creations, but dismissed this course of action as FEV had a tendency to render subjects sterile (defeating the whole purpose of the rats being invasive).
According to Enclave's research, this variety of the mole rats most closely resembles a Heterocephalus glaber, also known as the sand puppy or desert mole rats. Their increased size is likely due to exposure to heavy radiation. While larger than their ancestors, they don't appear to be any smarter. Their incisors show increased enamel and dentin growth, making them razor sharp. In addition, they display an incredible pain tolerance. They are relatively caring parents, willing to sacrifice their own life for the well-being of their pups. Mole rat families travel in groups of usually three to seven, consisting of two to three adults and one to four pups. These families are moderately docile, keeping to themselves unless approached by an enemy. Even though they are almost blind, they can smell and hear quite well.
Mole rats are usually found in small packs, usually away from the main populated areas. Although relatively weak, they can be a threat to lower level characters when encountered in large packs. Mole rats will attack if approached and usually charge at the player character.
Mole rat pups are mole rats that have yet to mature. Being younger, pups are smaller as well as weaker than adult mole rats. They are usually found around other mole rats, presumably their parents, wandering around the Mojave.