Four scattered diary pages detail the grisly end of the last human inhabitant of the farm, a lone child. According to the diary pages, the child's parents went to Camp Searchlight to procure supplies. Days passed and the parents did not return. The child went into the camp to search for them and found out that they had become feral ghouls due to the Legion's large radiation bomb event. The child's parents, now feral, attacked and tried to eat the child, so the child shot them and returned to the farm. Now, as the only human inhabitant, the child became increasingly paranoid and began accusing the farm animals of a violent conspiracy to overtake the farm. In a last, maniacal attempt to stop the animals, the child burned the farmhouse while still inside. The skeletal remains can be seen on the floor.
There are two old barns next to each other, one containing malnourished bighorners and the other malnourished brahmin, with both entrances facing east. Across from the barns is a burned down house. Inside is the skeleton of the previous owner, a child, and to the southeast are two graves which can be presumed to be mother and father's. Both of the graves are burial mounds which can be searched for loot (one may be labeled as a grave and require a shovel to open). To the right of the barns are three animal pens containing malnourished brahmin, malnourished brahmin calf and malnourished bighorner calf.
- A Wasteland Survival Guide skill book located on top floor of the northernmost barn along with torn diary page 3.
- A Sunset Sarsaparilla star bottle cap can be found on the top floor of the northernmost barn on top of a wooden crate next to some empty Sunset Sarsparilla bottles.
- Torn diary page 1 in the bighorner barn on the steps leading to the second floor.
- Torn diary page 2 in the back of the truck to the northeast.
- Torn diary page 3 in the northernmost barn on the 2nd floor on the wooden crate.
- Torn diary page 4 in the burnt down farmhouse to the northeast of the farm by the truck, near the skeleton.
Matthews Animal Husbandry Farm appears only in Fallout: New Vegas.