Part of the Massachusetts Turnpike eastbound highway in central Boston. A large group of raiders have set up a makeshift settlement near the entrance to Mass Pike Tunnel. The level of the highway turns into a trench and numerous ruined vehicles dot the highway roads.
- Cleansing the Commonwealth: Knight Rhys gives the Sole Survivor an assignment to clear the location of what he calls "abominations" to further the aims of the Brotherhood of Steel.
- Ghoul Problem: Settlers have asked the player character for help in taking care of some feral ghouls that have been terrorizing a nearby location.
- Quartermastery: Scribe Haylen has identified the location of a piece of technology she wishes to retrieve and catalog. She asks the Sole Survivor for help in bringing back the technology in one piece.
- Raider Troubles: A group of settlers is struggling to defend themselves against a nearby group of raiders and asks the Sole Survivor for help.
The Mass Pike Tunnel east appears only in Fallout 4.