Manya was born in 2213. At the age of 64, she is a sweet old lady. She and Nathan used to run a caravan line together and have managed to save enough caps and supplies to live out their retirement in Megaton. Manya's sweet exterior doesn't reveal that she's witnessed every misery that the wasteland has to offer. She is extremely wise and knowledgeable - two traits that allow her to continue to thrive and live in Megaton.
Occasionally Manya asks if anyone has seen her husband, Nathan. If one finds him and talks to him, she will still ask the Lone Wanderer if they have seen him. Nathan will also comment, wondering where Manya is.
If Nathan is killed, the player character will no longer be able to speak with Manya, instead she will simply acknowledge that he is dead, and if approached, will reply she was just thinking about him.
She may still ask the Lone Wanderer if they have seen Nathan even after his death.