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Lorenzo may refer to:
- Lorenzo Giovanni, the owner of the Friendly Lending Company in the Hub in Fallout.
- Senior Knight Lorenzo, a member of the Mojave Brotherhood of Steel in Fallout: New Vegas.
- Lorenzo Cabot, an archaeologist and the patriarch of the Cabot family in Fallout 4.
- Lorenzo, an employee at the National Isolated Radio Array before the Great War, mentioned in Fallout 76.
- Paul Lorenzo, an infant that resided in Vault 94's nursery, mentioned in the Fallout 76 update Nuclear Winter.
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