The Lewisburg station was a part of the long-defunct network of train stations scattered across Appalachia. At one point, it became the Lewisburg hub for operations and trading by the Responders, but has since been abandoned.
Lewisburg station lies on the southwestern edge of Lewisburg, sandwiched between Route 83A and the rail line leading east to Big Bend Tunnel West. Its front entrance lines up with the main road running through Lewisburg, though barricades and wrecked cars interfere with firing down the road at encroaching targets.
- Unsolved: Missing hikers - Note, tacked to the notice board.
- Missing: The Priblos - Note, tacked to the notice board.
- Power armor chassis with T-series armor pieces - East on the train tracks beside a derailed boxcar with "Jobs now or else!" written on it, halfway on the way to the Big Bend Tunnel West.
Lewisburg station appears only in Fallout 76.