In the 21st century, Lewisburg was a small town, though its unique welcoming atmosphere earned it the title of Coolest Small Town USA in a 2061 plebiscite. Lewisburg denizens went to great lengths to maintain that atmosphere, through a variety of initiatives including Sky Gardens (rooftop gardens cultivating produce, flowers, and helping keep the air clean and the community tight), art exhibitions at the local Serenity Road Art Gallery, and festivals in the streets of the city. The sole blight on this almost unbearably happy town was the Ash Heap, belching toxic ash in every direction and forcing the denizens of Lewisburg to use a gas mask on days with unfavorable weather.
Lewisburg survived the Great War largely unscathed and stayed organized for years after the war, independent and largely self-sufficient thanks to their sky gardens. Together with the sky bridges providing excellent overwatch positions, they could stand against wildlife and random ne'er-do-wells. Denizens of Lewisburg tried to preserve as much of their culture as they could as well and maintained the tradition of Spring Garden Festivals, which became major trading events as well, with stalls erected to barter weapons, armor, food, and other necessities. Unfortunately, during one of these festivals, raiders decided to exploit their momentary distraction and hit the town, taking to the rooftops and gunning the denizens down.
Lewisburg is a small town laid out in the shape of a square, with the two streets in the center dividing it into four neat quadrants. The southwest and southeast parts of the town offer little in the way of loot or interest. The northern two sectors flank a street where a festival was taking place, with stalls stretching all the way out to the northern end of the town.
Approaching from the west, Lewisburg's station can be seen on the first right; this road continues past the train station and leads to Monongah power substation MZ-03 and Big Bend Tunnel West. The road left climbs upward and turns right, leading to a series of open-air shops; of note, the open-air market includes an abandoned food kiosk and a small gun reseller. Lewisburg's main road contains more open-air shops; while most are of little interest, the cash registers can be a good source of pre-War money. A concert area comprises the northeast corner of the town and provides access to Pleasant Hills Cemetery to the north. There is a cooking station at the northern end of the main street, in the food stall.
The other sector contains the old art gallery on the northwestern corner and the visitors center in the southeast. The emergency exit in the courtyard grants access to the rooftops. The visitors center is worth checking out for the terminal entries and the attic, which contains a steamer trunk, accessible from the rooftops.
The back alleys offer stairs up to the roofs, connected by sky bridges, and topped with greenhouses. These provide a good source of fertilizer, ash rose, and access to the attic of the town hall, which contains a steamer chest. On the other end of the rooftops is another cooking station. Just southeast of the town, towards Big Bend Tunnel West, is a Bot-Stop, which is used in Bots on Parade.
- Order of Mysteries - Lewisburg - Holotape, on the body of Natasha Hunt during Initiate of Mysteries.
- Easy pickins - Note, on a roof next to the body of Kerry.
- Note to Lorri - Note, on the upper floor of the visitor's center sitting on a clipboard next to a working terminal.
- Kerry's orders - Note, on a dead raider on a roof during Initiate of Mysteries.
- Klein's notes, part 1 - Holotape, in a duffle bag in a rusted police patrol car. Found during The Lowe-Down.
- Klein's notes, part 2 - Holotape, next to two skeletons behind a house with a plastic flamingo in front of it (the house is northeast of the police patrol car where part 1 is found). Found during The Lowe-Down.
- Wolf check-in 64 - Note, in a cooler behind a house with a plastic flamingo in front of it. Near Klein's notes, part 2. Found during The Lowe-Down.
- Further instructions - Note, in a leather bag on a roof of a building across the road from Van Lowe Taxidermy (to the north). It is near a greenhouse containing ash roses. Found during The Lowe-Down.
- C.H. Monthly, January - Note, on the same roof of the greenhouse, outside.
- Mistress Natasha Hunt's login - On the body of Natasha Hunt during Initiate of Mysteries.
- Two potential Potential Vault-Tec bobbleheads:
- One on the upper floor of the visitor's center, near the restrooms, sitting on a wooden desk next to a radio.
- In the east-central block of the rooftop garden area of town, in the "rooftop living room" on top of the two-level white brick building, on a wooden crate near a couch.
- Potential magazine - Inside the malt shop, on the counter near a skeleton.
- Spare operative keycard - Key, in the leather bag that the Further instructions note is in.
Lewisburg appears only in Fallout 76.