The Karma syringe barrel is a weapon mod for Rose's syringer in Fallout 76.


When applied to Rose's syringer, the mod causes fired syringes to increase the target's Damage, Energy, and Radiation Resistance for 30 seconds. The target then suffers from decreased unarmed damage and reduced Damage, Energy, and Radiation Resistance for 60 seconds thereafter.

The mod decreases weapon accuracy while increasing range, Action Point cost, and aim transition time.


Psycho (1)
Steel (1)
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Flavors of Mayhem
Karma syringe barrel (1)


The Karma syringe barrel mod may be crafted and applied to Rose's syringer at a weapons workbench during the Flavors of Mayhem main quest.

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