Jacqueline Spencer was a young girl who lived with her parents in the settlement that was established within the ruins of University Point.
Jacqueline found an old hard drive with useful information that attracted the attention of the Institute, which then sent Conrad Kellogg to investigate. Following her father's refusal to leave the safety of the settlement and the abandoning of the wanted object, Kellogg decided to simply kill them all and take it by force.
A woman's body, presumably Jacqueline's, can be found next to the professor's terminal and a duffel bag containing a note from Jacqueline to her father stating that she was too late and the synths weren't far away.
Jacqueline Spencer appears only in Fallout 4.