Dr. Jacob Forsythe is one of the doctors of Vault 81 in the Commonwealth in 2287.


Doctor Jacob Forsythe is one of the resident doctors of Vault 81. He serves as more of a scientist, rather than a physician.

Interactions with the player characterEdit

Interactions overviewEdit

Perk nociception regulator
This character is essential. Essential characters cannot be killed.
Perk empathy synthesizer
This character is involved in quests.

Hole in the Wall

Other interactionsEdit

When the Sole Survivor first talks to Dr. Forsythe, he will ask that they give a blood sample for his research due to the fact that the vault dwellers have been "genetically isolated" while living in the vault. The Sole Survivor can refuse or accept to donate, or sell blood. Giving blood is a hidden requirement to start the quest Hole in the Wall.


Apparel Weapon Other items On death
Vault-Tec lab coat Overseer's room key


In a random encounter, the Sole Survivor may find a dead settler with a dead dog. The settler carries a note from Dr. Forsythe asking for a list of medical supplies, and instructing the carrier to use the intercom when they arrive.


Dr. Forsythe appears only in Fallout 4.

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