Upon entering, the home consists of a living room, a bedroom with an unowned bed on the immediate right, and a kitchen with a refrigerator and various minor loot. The home has a backdoor exiting out opposite the front door. It can be differentiated from the other houses in the area by the shopping cart in front of the entrance.
Isaac's house appears only in Fallout: New Vegas.
When passing by the house with an active quest marked on the map, the game becomes convinced that the path is *through* the house (it has a front and rear door aligned in the same general direction), thus concealing the actual quest item icon until the player character walks through the house or de/reselects the quest once having walked past the house. [verified]