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Isaac may refer to:
- John Isaac, a research assistant at the West Tek research facility, mentioned in Fallout.
- Isaac, a Gun Runner in Fallout: New Vegas.
- Bruce Isaac, a singer from New Reno hiding in Novac in Fallout: New Vegas.
- VMSTopsBruceIsaac.txt, dialogue for Bruce Isaac in Fallout: New Vegas.
- Isaac (Fallout 4), a programmer at General Atomics Galleria, mentioned in Fallout 4.
- Isaac Karlin, a scientist in the BioScience division of the Institute in Fallout 4.
- IsaacKarlin.txt, dialogue for Isaac Karlin in Fallout 4.
- Isaac Gant, a Cipher in Mesa Verde in Van Buren.
- Bring a GECK to Isaac in exchange for his power armor, a quest in Van Buren.
- Isaac dialogue file, dialogue for Isaac in Van Buren.
- Real-life person:
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