Described as difficult to figure out but passionate about his research, Dr. Henry previously worked with the Enclave on canine cyber-genetics. His specialization was in both human and canine neuroscience. He also worked on the development of a mutagenic serum, aiming to cure super mutants as an alternative to the Enclave's initiative to kill the afflicted. The doctor and Enclave leadership did not see eye to eye, enough so that Henry chose to leave. He tells the Courier that leaving was the right decision, as the Enclaveoil rig was destroyed shortly after his departure.
After leaving the Enclave, Dr. Henry integrated into the New California Republic, setting up a clinic in NCR town. Although some remnants of the Enclave will not speak about their past involvement with the group, one of the citizens of NCR town shares that they have heard about the Enclave from Henry, who spoke about it at length while drunk. His research gained the attention of Merk, the local crime lord, who sought assistance in stealing Henry's blueprints for building cybernetic canine guard units. As payment for assisting him with serum field work, Henry gives the Chosen One a cyberdog known as a Cyber-Hound Mk. II.
After moving on from NCR town, Dr. Henry spent time traveling with caravans, where he met with Gibson. He subsequently relocated to the Mojave Wasteland, joining other Enclave remnants fleeing death at the hands of the NCR and Brotherhood of Steel. He settled in Jacobstown, establishing his lab in the lodge. It is here that he researches the effects of prolonged Stealth Boy Mark II prototype usage by Nightkin, mentioning that his current lab is not as impressive as the facilities he had access to while in the Enclave. His primary objective is to cure the Nightkin's schizophrenia, but he is also capable of performing brain transplants for cyberdogs despite not having worked in the field recently.
According to the Fallout Bible, at some point after the destruction of Control station Enclave, Henry attempted to destroy a cyberdog named K-9 who was in Dorothy's care, fearing that too much information about the Enclave could be obtained from it.[Non-canon 1]
The Fallout Bible also mentions that his theories on correcting mutations in the wasteland were not popular with other Enclave scientists, such as Dr. Schreber.[Non-canon 2]
Sometimes he will not perform medical services for the player character. [verified]
Sometimes he may just say, "Keep your head down - there could be snipers around." This makes any communication with him impossible. There is no known fix for this bug, however, it may work to disable, enable, kill, and resurrect him using console commands. [verified]
↑Henry: "The Chosen One? Of course, that makes sense. Interesting... I'm afraid I can't help you. I was assigned to cyber-genetics research, not the Vault Behavioral Project." Chosen One: "Vault Behavioral project?" Henry: "Something about extreme sociological conditioning. Mind you, I thought it was all so much mumbo-jumbo, no real science in it at all. But I did hear something about 13 having to be improvised during the course of the experiment. Sloppy work, I'd say." (Dr. Henry's dialogue)
↑Arcade Gannon: "Doc Henry always was a hard one to figure out. It didn't seem to matter whether he was working with humans or dogs. He had an equal lack of affection for both. A regular Diogenes. I'm not sure what the man was after. Knowledge is power, but to what end for Henry, I have no idea. The problem was what mattered to him, not its practical impact. He simply solved riddles because they existed." (Arcade Gannon's dialogue)
↑ 3.03.13.2Courier: "You're a scientist?" Henry: "Yes. Specializing in neuroscience, both human and canine. Of course, this lab is nothing compared to what I had when I was with the Enclave." Courier: "Canine neuroscience?" Henry: "Cyber-dogs and the like. It's not a field I work in much anymore." (Henry's dialogue)
↑Henry: "Oh, it's a whole new field - very exciting. Why I'm working on some projects right now - a radical new concept for the mutant problem. You see, it's really quite simple - mutancy isn't absolute. It can be cured. I've prepared a small sample of the serum but it needs to be injected into a host." (Dr. Henry's dialogue)
↑Henry: "It must be used on a super-mutant. Inject the serum into a super-mutant and then come back and report the results. I understand Broken Hills is full of them." (Dr. Henry's dialogue)
↑ 6.06.1Courier: "You were with the Enclave?" Henry: "Yes, but the leadership and I didn't see eye to eye, so I left. It was the right decision, since the Enclave's oil rig was destroyed not long after." (Henry's dialogue)
↑Henry: "Of course, my simple-minded colleagues were just trying to solve the whole problem the crudest way possible. Purification, indeed. I'll admit there were some early problems, but I've got them worked out now...I think." (Dr. Henry's dialogue)
↑Doctor's papers: "A set of very detailed plans for a Cybernetic Canine Guard Unit. With this and the right facilities, a person just might be able to build a robo-dog."
↑Henry: "You'll be participating in an important experiment, in fact, the most important, scientific-oh, you mean money. Well, I do have a Cyber-Hound Mk. II, Personal Security Model, that I brought with me. I suppose I could have it activated and on-line by the time you got back. Would that do?" (Dr. Henry's dialogue)
↑Courier: "Doctor Henry sent me. I need a new brain for my cyber-dog." Old Lady Gibson: "Doctor Henry? Now there's a name I haven't heard in years. Hard to believe he's still alive." Courier: "How did you meet Doctor Henry?" Old Lady Gibson: "He and I had joined up with the same caravan. Add in a lot of whiskey, and, well, let's just say we got to know each other." (Old Lady Gibson's dialogue)
↑Courier: "Where did the Enclave go?" Arcade Gannon: "A lot of different places. I only know what I was told. Some of them were cut down by the NCR and the Brotherhood. Some of them went east. My mother never told me what happened to my father, but she and I went south with some others and integrated into the NCR. When the NCR learned that Enclave personnel had integrated, we kept moving to the fringes. It's one of the reasons why I wound up out here." Arcade Gannon's dialogue)
↑Courier: "What happened to Navarro?" Arcade Gannon: "After the Enclave's command structure fell apart, it was only a matter of time before Navarro was overrun by NCR forces. My mother and I left with some of the troopers from my father's old unit, the same people I've kept in contact with over the years. Anyone who didn't get out was killed by the NCR. Even some of the ones who escaped were eventually hunted down by the Brotherhood of Steel." Arcade Gannon's dialogue)
↑Henry: "The Nightkin have varying degrees of mental instability due their addiction to Stealth Boy use. I've been trying to come up with a cure." (Henry's dialogue)
↑Henry: "If you want me to transplant this brain into Rex, he'll become more durable." (Henry's dialogue)
↑Henry: "Oh, you'll need my word from the pass phrase to get into the bunker - "friends." Don't forget it.'" (Henry's dialogue)
↑Courier: "Arcade Gannon has asked me to gather all the former members of the Enclave in the Mojave." Henry: "I'm intrigued, so I'll go to this reunion. I'll be handing things over to Calamity, so talk to her if anything comes up.'" (Henry's dialogue)
↑Fallout Bible, K-9 (from Navarro): "After getting his motivator repaired, K-9 was left in NCR by the Chosen One so that he could receive necessary repairs from Dorothy and, not long after his recovery, Dr. Henry (who had been placed in critical condition after being reportedly assaulted by the Chosen One some time earlier). Dr. Henry, afraid that too much information about the Enclave would be obtained from K-9, attempted to destroy the cyborg, but was stopped by cyberdog and Dorothy, who suspected what Dr. Henry was planning. The NCR government used the attack as an excuse to confiscate K-9 and cyberdog in order to learn more information about the Enclave as well as what makes the two of them "tick." At last report (and over Dorothy's objections), K-9 and cyberdog were disassembled and analyzed. Structural damage during the disassembling is reported to have killed them both."
↑Fallout Bible 6: "4. In NCR there is a doctor (I don't remember his name) that works on an antidote for mutants. Unfortunately the antidote is lethal. I'm curious who is that guy because, according to the dialog, he seems to come from Enclave... or maybe he was just working there?" "Dr. Henry used to work with the Enclave cyber-genetic research program at the Poseidon oil rig and at various other Enclave installations. In NCR, Dr. Henry claims he left because he felt his "work wasn't being appreciated," which is true: his theories on correcting the mutation in the Wasteland population were not popular with the rest of the Enclave scientists, most notably one of his colleagues, Dr. Schreber, who he worked with jointly on many genetic research projects in the past. Dr. Henry was arguing with Schreber at the Navarro base about the mutation problem for the five billionth time when Schreber, in a fit of anger, told Henry he was going to recommend that Henry be transferred to another Enclave facility where he would be put to work on cybernetic maintenance (the equivalent of cybernetic janitorial duty). Henry took the threat very seriously, and within hours, Dr. Henry stole a cybernetic dog (cyberdog) and slipped away from the Navarro facility, heading east and eventually making his way to NCR. The Enclave, while not pleased with his attitude and the directions of his research, were not happy with his escape (they need all the scientists they can get), and several soldiers were punished for negligence. Schreber never confessed to his role in Henry's disappearance, and simply claimed that Dr. Henry had been acting suspicious for some time, and was displaying 'sympathies for the mainland mutants.'"