As with all houses in Tranquility Lane, it has two stories with the front door entering into the lounge, which in addition to the normal lounge furniture items, features a chandelier, Radiation King radio, and robotic assistance in the form of a Mister Handy. The other ground level rooms are a kitchen, which contains a terminal, and a bathroom. Upstairs, the house has another bathroom and a bedroom with two single beds. At the top of the stairs, there is a roller skate found on the floor.
- The Henderson residence contains a number of special items that can be interacted with to complete Betty's tasks, namely: the chandelier, roller skate, oven, computer terminal, and Mister Handy.
- When first entering this residence the Lone Wanderer can detect a "radio signal" which is unnamed and cannot be received, due to the fact that they can't access their Pip-Boy 3000. This is likely because there is a radio inside which can be turned on but the option to do so was withheld during development. Only static will be heard, though.
- If one uses console commands to noclip under the house, there's a terminal underneath it. The Lone Wanderer can talk to it, and it responds with "yeah" and "later."
The Henderson residence appears only in Fallout 3.