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A holotape in the Memory Den during the quest Memory Interrupted reveals that H2-22 decided to wipe his memory to start a new life. After the quest is complete, Desdemona will inform the player character that H2-22 has safely escaped the Commonwealth.
Interactions with the player character
|This character is essential. Essential characters cannot be killed.|
|This character is involved in quests.|
- Boston After Dark: The Sole Survivor must help H2 get to a safe house with the aid of High Rise.
- Memory Interrupted: The way for H2 to be escorted has been plagued by Institute synths, the Sole Survivor must help clear the way.
- Even though Nick Valentine claims that all synths who escape the Institute lose their memories of it, due to a manufactured failsafe, H2-22 can recall many details of his life there. It is later revealed by DiMA that Nick had new memories uploaded to him just before the two of them escaped, coupled with the early synth's limited memory capacity caused Nick to not remember the Institute.
- H2-22's appearance is based on his actor Ryan Alosio.
H2-22 appears only in Fallout 4.